Purvalanol B( NG-95 )

Catalog No. M13388 CAS No. 212844-54-7

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Datasheet

HNMR

HPLC

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Product Name

Purvalanol B
Note

Research use only, not for human use.
Brief Description

A potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively.
Description

A potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively; no inhibition for cdk4/cyclin D1 (>10 uM); has no effect on Erk1, PKC, Raf, CK1, CK2.
In Vitro

Purvalanol B binds to P. falciparum casein kinase 1 (CK1) from blood stage cell lysates and inhibits the growth a chloroquine-resistant strain of P. falciparum (FCR-3) with an IC50 of 7.07 μM.
In Vivo

——
Synonyms

NG-95
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

Cancer
Indication

——

CAS Number

212844-54-7
Formula Weight

432.9039
Molecular Formula

C20H25ClN6O3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 40 mg/mL
SMILES

CC(C)N1C2=NC(N[C@H](C(C)C)CO)=NC(NC3=CC(Cl)=C(C(O)=O)C=C3)=C2N=C1
Chemical Name

Benzoic acid, 2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]-

1. Gray NS, et al. Science. 1998 Jul 24;281(5376):533-8. 2. Chang YT, et al. Chem Biol. 1999 Jun;6(6):361-75.

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