Purvalanol B

CAS No. 212844-54-7

Purvalanol B ( NG-95 )

Catalog No. M13388 CAS No. 212844-54-7

A potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 60 In Stock
10MG 78 In Stock
25MG 136 In Stock
50MG 203 In Stock
100MG 305 In Stock
200MG 461 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Purvalanol B
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively.
  • Description
    A potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively; no inhibition for cdk4/cyclin D1 (>10 uM); has no effect on Erk1, PKC, Raf, CK1, CK2.
  • Synonyms
    NG-95
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    212844-54-7
  • Formula Weight
    432.90
  • Molecular Formula
    C20H25ClN6O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 40 mg/mL
  • SMILES
    CC(C)N1C2=NC(N[C@H](C(C)C)CO)=NC(NC3=CC(Cl)=C(C(O)=O)C=C3)=C2N=C1
  • Chemical Name
    Benzoic acid, 2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gray NS, et al. Science. 1998 Jul 24;281(5376):533-8.
2. Chang YT, et al. Chem Biol. 1999 Jun;6(6):361-75.
molnova catalog
related products
  • JSH-150

    JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM).

  • Ro-3306

    Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively.

  • BQU57

    BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.